Plasma exosomal miR-125a-5p and miR-141-5p as non-invasive biomarkers for prostate cancer

Predictive biomarkers for early diagnosis of prostate cancer are important its treatment. The functional microRNAs in the exosomes plasma and serum samples interest as stable non-invasive recurrence patients. present study aimed to clarify value exosomal miRNA-125a-5p miR-141-5p cancer. included 19 healthy individuals 31 In comparison levels controls, showed a slight increase patients (p=0.085), miR-125a-5p that significant decrease with than controls (p=0.032). As derived parameter, miR-125a-5p/miR-141-5p ratio was significantly higher (p<0.001). We found promise distinguishing AUC 0.652, miR-125a-5p, 0.691. For ratio, 0.793. has weak positive correlation PSA (correlation coefficient = 0.3413). Moreover, been hold negatively no-significant PSA, is -0.1102. speculate that, diagnostic markers cancer, miR-125-5p might be independent PSA. summary, results this suggest high expression miR-141-3p low from useful specific tumor traits associated seems perform better either single values alone.